We invite postgraduate research proposals in a number of disease areas that impact significantly on patient care. We focus on exploring the mechanisms of disease, understanding the ways disease impacts patients' lives, utilising new diagnostic and therapeutic techniques and developing new treatments.
As a student in Biomedicine you will be registered with a University research institute, for many this is the Institute for Cellular Medicine (ICM). You will be supported in your studies through a structured programme of supervision and training via our Faculty of Medical Sciences Graduate School.
We undertake the following areas of research and offer MPhil, PhD and MD supervision in:
Applied immunobiology (including organ and haematogenous stem cell transplantation)
Newcastle hosts one of the most comprehensive organ transplant programmes in the world. This clinical expertise has developed in parallel with the applied immunobiology and transplantation research group. We are currently investigating aspects of the immunology of autoimmune diseases and cancer therapy, in addition to transplant rejection. We also have themes to understand the interplay of the inflammatory and anti-inflammatory responses by a variety of pathways, and how these can be manipulated for therapeutic purposes. A further research theme is focusses on primary immunodeficiency diseases.
Find out more about applied immunobiology research, projects and staff specialisms.
There is a strong emphasis on the integration of clinical investigation with basic science. Our research themes include:
- cell signalling in normal and diseased skin including mechanotransduction and response to ultraviolet radiation
- dermatopharmacology including mechanisms of psoriatic plaque resolution in response to therapy
- stem cell biology and gene therapy
- regulation of apoptosis/autophagy
- non-melanoma skin cancer/melanoma biology and therapy
We also research the effects of UVR on the skin including mitochondrial DNA damage as a UV biomarker.
Find out more about dermatology research, projects and staff specialisms.
This area places emphasis on translational research, linking clinical- and laboratory-based science. Our key research themes include:
- mechanisms of insulin action and glucose homeostasis
- insulin secretion and pancreatic beta-cell function
- diabetic complications
- stem cell therapies
- genetics and epidemiology of diabetes
Find out more about diabetes research, projects and staff specialisms.
Diagnostic and therapeutic technologies
Our focus is on applied research and aims to underpin future clinical applications. Technology-oriented and demand-driven research is conducted which relates directly to health priority areas such as:
- bacterial infection
- chronic liver failure
- cardiovascular and degenerative diseases
This research is sustained through extensive internal and external collaborations with leading UK and European academic and industrial groups, and has the ultimate goal of deploying next-generation diagnostic and therapeutic systems in the hospital and health-care environment.
Find out more about diagnostic and therapeutic technologies research, projects and staff specialisms.
There are a number of research programmes into the genetics, immunology and physiology of kidney disease and kidney transplantation. We maintain close links between basic scientists and clinicians with many translational programmes of work, from the laboratory to first-in-man and phase III clinical trials. Specific areas of interest include:
- haemolytic uraemic syndrome
- renal inflammation and fibrosis
- the immunology of transplant rejection
- tubular disease
- cystic kidney disease
We have particular interests in:
- primary biliary cirrhosis (epidemiology, immunobiology and genetics)
- alcoholic and non-alcoholic fatty liver disease
- the genetics of other autoimmune and viral liver diseases
Magnetic Resonance (MR), spectroscopy and imaging in clinical research
Novel non-invasive methodologies using magnetic resonance are developed and applied to clinical research. Our research falls into two categories:
- MR physics projects involve development and testing of new MR techniques that make quantitative measurements of physiological properties using a safe, repeatable MR scan.
- Clinical research projects involve the application of these novel biomarkers to investigation of human health and disease.
Our studies cover a broad range of topics (including diabetes, dementia, neuroscience, hepatology, cardiovascular, neuromuscular disease, metabolism, and respiratory research projects), but have a common theme of MR technical development and its application to clinical research.
Find out more about Magnetic Resonance (MR), spectroscopy and imaging in clinical research, projects and staff specialisms.
Musculoskeletal disease (including auto-immune arthritis)
We focus on connective tissue diseases in three, overlapping research programmes. These programmes aim to understand:
- what causes the destruction of joints (cell signalling, injury and repair)
- how cells in the joints respond when tissue is lost (cellular interactions)
- whether we can alter the immune system and