For more information about Genetics at Newcastle University, please visit the webpage using the button above.

The award
MPhil

How long you will study
12 months

Domestic course fees
find out

How you will study
full-time

Course starts
find out

International course fees
find out

All study options

About Genetics at Newcastle University

The Institute of Genetic Medicine brings together a strong team with an interest in clinical and developmental genetics. Our research focuses on the causes of genetic disease at the molecular and cellular level and its treatment. Research areas include: genetic medicine, developmental genetics, neuromuscular and neurological genetics, mitochondrial genetics and cardiovascular genetics.

As a research postgraduate in the Institute of Genetic Medicine you will be a member of our thriving research community. The Institute is located in Newcastle's Life Science Centre. You will work alongside a number of research, clinical and educational organisations, including the Northern Genetics Service.

Quality and Ranking

We rank in the top 100 for Medicine - QS World University Rankings by Subject 2019.

Find out more about the Institute of Genetic Medicine's research areas. We offer supervision for MPhil, PhD and MD in the following research areas:

Cancer genetics and genome instability

Our research includes:

  • a major clinical trial for chemoprevention of colon cancer
  • genetic analyses of neuroblastoma susceptibility
  • research into Wilms Tumour (a childhood kidney cancer)
  • studies on cell cycle regulation and genome instability.

Cardiovascular genetics and development

We use techniques of high-throughput genetic analyses to identify mechanisms where genetic variability between individuals contributes to the risk of developing cardiovascular disease. We also use mouse, zebrafish and stem cell models to understand the ways in which particular gene families' genetic and environmental factors are involved in the normal and abnormal development of the heart and blood vessels.

Complex disease and quantitative genetics

We work on large-scale studies into the genetic basis of common diseases with complex genetic causes, for example autoimmune disease, complex cardiovascular traits and renal disorders. We are also developing novel statistical methods and tools for analysing this genetic data.

Developmental genetics

We study genes known (or suspected to be) involved in malformations found in newborn babies. These include genes involved in normal and abnormal development of the face, brain, heart, muscle and kidney system. Our research includes the use of knockout mice and zebrafish as laboratory models.

Gene expression and regulation in normal development and disease

We research how gene expression is controlled during development and misregulated in diseases, including the roles of transcription factors, RNA binding proteins and the signalling pathways that control these. We conduct studies of early human brain development, including gene expression analysis, primary cell culture models, and 3D visualisation and modelling.

Genetics of neurological disorders

Our research includes:

  • the identification of genes that in isolation can cause neurological disorders
  • molecular mechanisms and treatment of neurometabolic disease
  • complex genetics of common neurological disorders including Parkinson's disease and Alzheimer's disease
  • the genetics of epilepsy.

Kidney genetics and development

Kidney research focuses on:

  • atypical haemolytic uraemic syndrome (aHUS)
  • vesicoureteric reflux (VUR)
  • cystic renal disease
  • nephrolithiasis to study renal genetics.

The discovery that aHUS is a disease of complement dysregulation has led to a specific interest in complement genetics.

Mitochondrial disease

Our research includes:

  • investigation of the role of mitochondria in human disease
  • nuclear-mitochondrial interactions in disease
  • the inheritance of mitochondrial DNA heteroplasmy
  • mitochondrial function in stem cells

Neuromuscular genetics

The Neuromuscular Research Group has a series of basic research programmes looking at the function of novel muscle proteins and their roles in pathogenesis. Recently developed translational research programmes are seeking therapeutic targets for various muscle diseases.

Stem cell biology

We research human embryonic stem (ES) cells, germline stem cells and somatic stem cells. ES cell research is aimed at understanding stem cell pluripotency, self-renewal, survival and epigenetic control of differentiation and development. This includes the functional analysis of genes involved in germline stem cell proliferation and differentiation. Somatic stem cell projects include programmes on umbilical cord blood stem cells, haematopoietic progenitors, and limbal stem cells.

Facilities

We have specialist facilities on-site for:

  • multicolour fluorescence-activated cell sorting
  • ‘next generation’ high-throughput sequencing and genotyping
  • transgenics/gene targeting
  • confocal microscopy
  • optical projection tomography
  • gene expression imaging
  • microarray technology
  • bioinformatics
  • fluorescent activated cell sorting
  • ‘Good Manufacturing Practice’ for human stem cells.

Find out more about the Institute of Genetic Medicine's facilities.

Study options for this course

  • The award How you will study How long you will study Course starts Domestic course fees International course fees
  • The awardMPhilHow you will studyFull-timeHow long you will study12 months
    Course starts find outDomestic course fees find outInternational course fees find out
  • The awardPhDHow you will studyFull-timeHow long you will study36 months
    Course starts find outDomestic course fees find outInternational course fees find out
  • The awardMDHow you will studyFull-timeHow long you will study24 months
    Course starts find outDomestic course fees find outInternational course fees find out
  • The awardMPhilHow you will studyPart-timeHow long you will study24 months
    Course starts find outDomestic course fees find outInternational course fees find out
  • The awardPhDHow you will studyPart-timeHow long you will study72 months
    Course starts find outDomestic course fees find outInternational course fees find out
  • The awardMDHow you will studyPart-timeHow long you will study48 months
    Course starts find outDomestic course fees find outInternational course fees find out

Notes about fees for this course

See Fees and Funding tab in the Programme information in our online Prospectus. https://www.ncl.ac.uk/postgraduate/courses/degrees/genetics-mphil-phd-md/?utm_source=referral-study-link&utm_medium=course-listing&utm_content=genetics-mphil-phd-md&utm_campaign=PG3PL-study-link#fees&funding

Entry requirements

MPhil

A 2:1 honours degree, or international equivalent, in a science or medicine related subject.

PhD

A 2:1 honours degree, or international equivalent. Further research experience or a Master's degree would be advantageous.

MD

A MBBS, or an equivalent medical degree.

International Students

To study this course you need to meet the following English Language requirements:

IELTS 6.5 overall (with a minimum of 5.5 in all other sub-skills).

Our typical English Language requirements are listed as IELTS scores but we also accept a wide range of English Language tests.

The equivalent academic qualifications that we accept are listed on our country pages.

You may need an ATAS (Academic Technology Approval Scheme) clearance certificate. You'll need to get this before you can get your visa or study on this programme. We'll let you know about the ATAS requirement in your offer letter.

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