Czech Republic (the)
Faculty of Science, Charles University| The award | How you will study | Study duration | Course start | Domestic course fees | International course fees |
|---|---|---|---|---|---|
| PhD | Full-time | - | - | - | - |
The aim of this thesis will be to approach model bacterial systems (such as E. coli and Mycoplasma) that are used in minimal cell development research. The genomes of these model organisms have already been successculy reduced in the genome/proteome size and on the level of the information-carrying DNA. However, no study so far limited the number of the amino acids that compose the proteome. Such a reduction would lead to energetic savings and uncover whether cells could function with less than 20 amino
acids to compose their proteins. We have already learnt that proteins could work with a much smaller amino acid repertoire in vitro. This thesis will focus on whole biological systems using genome engineering and laboratory evolution. Initially, the dispensability of selected amino acids will be compared for the studied bacterial systems using starvation experiments. The amino acid that will be most dispensable will then be substituted in exemplary metabolic pathways using genome engineering technique and broad randomization schemes. This thesis will explore whether an extant biological system can cope with removal of one (or more) amino acid from its proteome, how significant mark it would leave and whether cells could adapt to it by forward evolution.
Contact Faculty of Science, Charles University to find course entry requirements.
Below are some suggested courses at other providers that you may also be interested in:
Double Bachelor in Econometrics and Philosophy of Econometrics BA/BSc Combined Honours
Erasmus School of Economics, Erasmus University Rotterdam
Find out more
Brain and Cognition Master Degree
Erasmus School of Social and Behavioural Sciences (ESSB), Erasmus University Rotterdam
Find out moreIf you do not meet the entry requirements for this course then consider one of these postgraduate preparation courses from another institution:
There are 136 other courses listed from Faculty of Science, Charles University. A selection of these are displayed below:
A postdoctoral position to study thermal effects in landslides Postdoc
Faculty of Science, Charles University
Find out more Activation of STING signaling in tumors associated with human papillomaviruses PhD
Faculty of Science, Charles University
Find out more Advanced Electron Microscopy Techniques for the Characterization of Tunable Zeolitic Architectures PhD
Faculty of Science, Charles University
Find out more Amphiphilic Peptidomimetics Containing Metallacarboranes as a Design Strategy for Future Antibiotics PhD
Faculty of Science, Charles University
Find out more Join the StudyLink email list and never miss a chance to turn your study abroad dreams into reality!
See other universities in Prague
Find out more about studying in Czech Republic (the)
