School members form part of the Centre for Biochemistry and Cell Biology (CBCB). Current research focuses on the molecular mechanisms of growth, development and adaptation in both health and disease. The techniques employed include molecular biology, cell culture, microinjection, proteomic analysis, microarray screening, advanced imaging techniques, molecular structure determination and modelling. Most of the research in the Centre is conducted in vitro or in tissue and organ culture. Increasingly, we expect to use computational analysis and simulation. One of the research groups in the Centre is especially dedicated to developing alternatives to animal experimentation. The Centre is heavily involved in the use and development of genomic, proteomic and imaging technologies in two of the technology clusters of the University (Post-genomic Technologies Cluster and Imaging Cluster). Also the Centre has strong links, through collaboration and shared technology, to the Institute of Genetics, the Institute of Neurosciences, the Centre for Integrated Biology and Medicine and the Institute of Experimental Therapeutics.
The Centre has particular strengths in the following areas:
- Signal transduction in proliferation and inflammation; intracellular trafficking
- Post-translational modification of transcription factors and chromatin remodelling
- Proteasome structure and function, neurodegeneration
- Ubiquitin, ubiquitin binding proteins, ubiquitin ligases and ubiquitin-like proteins
- Regulation of lipid metabolism
- Structure of membranes, membrane proteins and transport across membranes
- Cardiovascular development, cell adhesion and bacterial pathogens
- DNA recombination and repair
- Tumour suppression and protein trafficking
- Structure and function of STAT proteins.