ANTI FUN-GAL: Antifungal Prodrugs to Evade Drug Resistance, PhD

Faculty of Science, Charles University, Czech Republic (the)

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The award	How you will study	Study duration	Course start	Domestic course fees	International course fees
PhD	Full-time	find out	find out	find out	find out

About ANTI FUN-GAL: Antifungal Prodrugs to Evade Drug Resistance, PhD - at Faculty of Science, Charles University

Project Summary:

Invasive fungal infections are difficult to treat due to the increasing resistance of fungal species to current treatment and the limited number of available antifungal drugs.1,2 In December 2022, World Health Organization (WHO) published the first list of priority fungal infections threatening public health.3 Pathogenic fungi cause the most significant burden among susceptible individuals, e.g., immunocompromised, organ transplants, or cancer patients. Presence of fungal strains resistant to clinically used antifungals represents the biggest challenge of current decade. Fungal pathogens use several mechanisms leading to drug resistance ranging from drug efflux to chromosomal duplication or target site mutation.4,5 Moreover, resistant invasive mycoses can also develop secondary resistance in response to the current treatment.6,7 Several species (e.g., Aspergillus) have reduced susceptibility to the currently used antifungal drugs resulting in pan-resistance. Prodruging current antifungal drugs overrides toxicity of drugs and drug resistance of fungal pathogens by circumventing common biological barriers, and consequently saves time and money in developing new chemical entities.

Learn more about ANTI FUN-GAL: Antifungal Prodrugs to Evade Drug Resistance, PhD - at Faculty of Science, Charles University

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Entry requirements

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Fees, Funding and Scholarships at Faculty of Science, Charles University

This text facilitates quick navigation of the various types of scholarships but does not provide a full list of rules and policies regulating this field. The granting and payments of scholarships is governed primarily by the Scholarships and Bursaries Rules of Charles University (cuni.cz/UKEN-727.html), the Rules for Granting Scholarships at FSc, and the relevant measures issued by the Dean (natur.cuni.cz/fakulta/studium/bc-nmgr/predpisy-a-poplatky/stipendia; Czech only).

Students may obtain the following scholarships:

accommodation bursary;
bursary for a student in difficult social circumstances;
scholarship for outstanding academic achievement (“mark-based”);
bursary in a case worthy of special consideration;
bursary to support study abroad;
bursary for a CU student in an acutely difficult situation;
bursary to support study in the Czech Republic;
bursary for excellent research, development, innovation, artistic, or other creative achievements contributing to enhanced knowledge;
scholarship for RDI (research, development, and innovation) under special legislation;
motivation bursary for 1st year bachelor’s programme students;
motivation bursary for 1st year post-bachelor’s programme students;
sports bursary;
doctoral bursary.

Certain scholarships are granted to students automatically (without student applications), whereas others are granted further to an application (electronic or paper, depending on the type of scholarship). Bursaries are neither taxed nor included in stated income. You can find answers to frequently asked questions regarding scholarships on the Faculty website (natur.cuni.cz/fakulta/studium/helpdesk/faq-stipendia; Czech only).

For more information check our dedicated website.